CORDIS Project
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This project investigates the genetic and functional characteristics of non-leukemic B-cells in patients with chronic lymphocytic leukemia. The goal is to understand the biological basis of the disease and identify potential prevention strategies.
B-cell chronic lymphocytic leukemia (CLL) is a frequent B-cell leukemia of unknown etiology with the strongest familial inheritance among lymphoproliferative disorder.
A key finding about CLL cells is that derive from autoreactive B lymphocytes, exhibit stereotyped Abs structures, and poly/auto-reactivity.Our long term goal is to prevent CLL by understanding the biology at the basis of CLL ontogeny.Our hypothesis is that an inherited CLL predisposition causes alterations in pre-leukemic B cells…
UNIVERSITA DEGLI STUDI DI GENOVA
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