CORDIS Project
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This project investigates how aging affects bone's ability to adapt to mechanical loading, particularly in female mice. It aims to understand the role of bone-forming cells in this process and explore methods to enhance bone health in aging populations or conditions like paralysis.
Osteoporosis is an age and gender-related condition characterised by reduced bone mass, impaired micro-architecture and increased risk of low-trauma fractures.
Osteoporosis-related fractures are a major health concern and impose a huge economic burden on European health care systems.
In the young, bone adapts its mass and architecture in response to strains engendered by mechanical loading.
However, this response in blunted in the aged.
We have shown that the anabolic response to load is similar…
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