CORDIS Project
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This project uses advanced imaging and computational techniques to study how blood vessels form and remodel in development and disease. By analyzing endothelial cell shapes and their signaling environments, it aims to uncover the principles behind vascular patterning.
Current angiogenesis research using genetic loss-of function approaches in mouse and zebrafish models provides for a growing number of genes implicated in blood vessel formation.
Mechanistic insight often remains unsatisfactory as phenotypes fall into common categories.
Our recent cell competition models combined with computational analysis have transformed the way we can study mechanisms in vascular patterning.I propose to systematically exploit mosaic analysis in vivo to deconstruct vascular p…
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