CORDIS Project
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This project focuses on understanding tissue-resident natural killer cells in humans, particularly their formation and regulation in organs like the liver and uterus. It employs advanced surgical techniques and single-cell technologies to investigate immune responses and tissue dynamics.
Natural killer (NK) cells contribute to tumor and antiviral immunity, regulate immune homeostasis, and impact on pregnancy success.
These functions are in many instances performed in peripheral organs.
Recent pioneering research in mouse models has revealed the existence and self-maintenance of tissue-resident (TR) NK cells.
Although similar mechanisms are assumed to occur in humans, this has never been formally demonstrated and with our diverse infection history and active microbiota the human…
KAROLINSKA INSTITUTET
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