CORDIS Project
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This project seeks to understand and overcome resistance to targeted cancer therapies by establishing patient-derived models. It focuses on elucidating the mechanisms of resistance and testing new strategies to enhance treatment efficacy.
Over the past 10 years, the chemotherapeutic arsenal has been expanded to include molecular-targeted therapies based on the principle that cancer cells become addicted to a single driver oncogene.
However, use of these new therapies is limited due to development of acquired resistance.
To fully understand how resistance develops, patient-derived models are an absolute pre-requisite, but establishing them remains extremely challenging.
Few groups worldwide have successfully implemented a systemat…
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