CORDIS Project
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This project investigates the role of the irradiated microenvironment in recurrent glioblastoma, aiming to identify new therapeutic targets. By utilizing advanced techniques like spatial transcriptomics and single-cell RNA sequencing, it seeks to uncover how the treatment environment influences tumor resistance and dev…
Gliomas are the most common brain tumors and the highest-grade glioma, glioblastoma (GBM), is arguably the most aggressive tumor type, with no long-term survivors.
Patients with GBM are treated with radiotherapy, chemotherapy, surgery, and tumor treating fields.
Despite initial response all tumors recur as incurable lesions; there is an urgent need for novel therapeutic approaches for this patient group.
The majority of GBMs recur within the treatment field receiving high-dose radiotherapy durin…
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