CORDIS Project
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This project focuses on understanding the clonal expansion of hematopoietic stem cells and its role in diseases like VEXAS syndrome, which is linked to aging. It aims to develop innovative technologies to study genetic mutations and inflammatory processes in patients, potentially leading to new treatment strategies.
Hematopoietic stem cells (HSCs) accumulate somatic mutations during aging, which may drive clonal expansion of their progeny.
This clonal imbalance promotes cancer and often establish systemic inflammation contributing to frequent diseases of aging.
Disentangling and tackling clonal imbalance of hematopoiesis is thus an urgent challenge with substantial medical implications for a progressively aging population. VEXAS syndrome is a novel, adult-onset, devastating disease with growing number of pa…
OSPEDALE SAN RAFFAELE SRL
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