CORDIS Project
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This project investigates DNA replication processes to understand how oncogene activation and anti-cancer drugs affect genome stability. By analyzing cellular responses to replication stress, the research aims to identify mechanisms that contribute to tumorigenesis and the cytotoxic effects of chemotherapy, particularl…
DNA replication is a crucial, but potentially dangerous process in every cellular division. A failure to maintain the integrity of replicating chromosomes leads to genome instability, an early event in tumorigenesis.
Most common anti-cancer drugs also interfere with DNA synthesis, by largely undefined mechanisms.
My lab specializes in the structural and molecular characterization of DNA replication stress in higher eukaryotes, combining standard cell and molecular biology with specialized single…
University of Zurich
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