CORDIS Project
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The project investigates the antiviral mechanisms in fruit flies, specifically focusing on how certain genes restrict viral replication in reproductive cells. It aims to enhance understanding of innate immunity and its implications for human health.
Like mammals, insects are infected by many viruses.
Among them, arthropod-borne viruses are an increasing worldwide health concern.
Insects have potent innate antiviral defenses, of which RNA interference (RNAi) is the main and best studied.
In the fruitfly Drosophila melanogaster, the siRNA pathway controls viral replication in somatic tissues.
The piRNA pathway, another RNAi based response, acts specifically in the reproductive tract (germline and follicular cells (FC), a monolayer of somatic…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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