CORDIS Project
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This project investigates how persister cells, which are resistant to antibiotics, can resume growth after antibiotic treatment. Using Salmonella as a model, the research focuses on the mechanisms of persister resuscitation and the role of specific toxins and detoxifying enzymes in this process.
This proposal aims to provide insight into persister resuscitation.
Persisters are multidrug-tolerant cells that are transiently non-growing and able to generate viable offspring by resuming growth when antibiotic pressure is removed.
Despite their implication in relapses of many infectious diseases, and progress in understanding how persisters form through the action of toxin-antitoxin modules, the mechanisms underlying resuscitation of these persisters are still unknown.
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