CORDIS Project
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This project investigates how the retromer complex facilitates the transport of proteins and lipids within cells by studying its role in membrane bending and vesicle formation. It employs advanced imaging techniques to analyze the dynamics of cargo molecules related to diseases such as Alzheimer's.
Transportation of proteins and lipids between membrane-enclosed organelles by vesicle formation is a fundamental task in eukaryote cells.
The least understood protein complex involved in membrane remodelling for vesiculation, but with a wide range of medical implications, is the retromer complex.The objective of this proposal is:First, to identify the mechanistic principles of membrane bending and scission by retromer, and second to characterize temporal and morphological aspects of retromer and…
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