CORDIS Project
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This research focuses on understanding how genes are expressed in single cells, particularly the differences between expressing both gene copies and just one. By analyzing single-cell transcriptomes, it aims to reveal how variations in gene expression can lead to different traits in genetically identical individuals.
As diploid organisms inherit one gene copy from each parent, a gene can be expressed from both alleles (biallelic) or from only one allele (monoallelic).
Although transcription from both alleles is detected for most genes in cell population experiments, little is known about allele-specific expression in single cells and its phenotypic consequences.
To answer fundamental questions about allelic transcription heterogeneity in single cells, this research program will focus on single-cell transcrip…
KAROLINSKA INSTITUTET
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