CORDIS Project
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This project investigates why vaccine effectiveness varies between populations, particularly in low and middle-income countries compared to Europe. It aims to understand the underlying immunological and metabolic factors and develop interventions to enhance vaccine responses through clinical trials and advanced cellula…
Prevention of infectious diseases through vaccination is one of the greatest achievements of medicine, yet there is growing realisation that vaccine immunogenicity and efficacy varies greatly across populations in high- versus low/middle- income countries (LMIC) and in urban- versus rural areas within one country.
For example, whereas vaccination of volunteers in Europe with attenuated malaria vaccine can result in 100% protection, the efficacy drops to only 29% when tested in Africa, where it i…
Leiden University Medical Center
ACADEMISCH ZIEKENHUIS LEIDEN
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