CORDIS Project
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This project uses a reversible intestinal infection model to study immune responses to commensal and pathogenic bacteria. It aims to differentiate between immune induction by commensals and immune evasion by pathogens, providing insights for vaccine development and understanding chronic inflammatory diseases.
The research described in this proposal will use a novel reversible intestinal infection model developed in my laboratory (Hapfelmeier et al., 2010.
Science 328:1705-1709) for the detailed study of the differences between intestinal commensal and pathogen induced immunity.
In my earlier work this system allowed fully reversible intestinal exposure of germ-free animals with live bacteria so that the commensal-induced immunity could be uncoupled from persistent bacterial colonization.
This permitt…
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