CORDIS Project
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The REVERT project investigates how injuries in the gastrointestinal tract affect stem cells and their interactions with the microbiota. It aims to understand the consequences of differentiated cells reverting to a stem cell state and how this impacts tissue repair and microbial ecology.
Tissues with high turnover are hierarchically organized and rely on long-lived stem cells that are protected by a variety of mechanisms.
In the gastrointestinal tract, highly active stem cells are located in the base of crypts, where differentiated cells shield them from environmental threats.
It has recently emerged that mucosal injuries initiate regenerative repair programs that promote a disruption of cellular hierarchies and reversal of differentiated cells back to the proliferative stem cel…
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