CORDIS Project
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This project focuses on enhancing T cell therapies for cancer treatment by targeting a specific receptor that impairs T cell function within tumors. The research aims to develop monoclonal antibodies that can improve T cell infiltration and effectiveness against various cancers, paving the way for better immunotherapy…
T cell infiltration and persistence in solid tumors are crucial for the success of T cell-based immunotherapies, yet the tumor microenvironment (TME) often suppresses T cell access and function.
Our ERC-funded research has identified a G protein-coupled receptor (GPCR), activated by a metabolite commonly enriched in solid tumors, that substantially impairs T cells.
We showed that inhibition of this GPCR enhances T cell infiltration, persistence, and cytotoxicity, thereby substantially improving…
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
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