CORDIS Project
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This project aims to investigate G-quadruplex structures in DNA, which play a significant role in cellular processes and genomic stability. It focuses on understanding the mechanisms that resolve these structures to better comprehend their biological implications.
G-quadruplex (G4) structures are stable four-stranded nucleic acids assemblies that can form in guanine-rich DNA.
Their recent visualization in mammalian cells has established G4 structure formation throughout the genome and fueled research into understanding the biological implications of these structures in cell regulation. G4 sequence motifs are abundant and conserved in our genome. G4 structures form transiently and regulate numerous cellular processes such as DNA replication, transcription…
KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
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