CORDIS Project
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This project aims to understand how the complex structure of articular cartilage develops and how to regenerate it after injury. By studying mechanical influences on cartilage development, it seeks to identify pathways that could enhance cartilage repair and improve patient outcomes.
Articular cartilage (AC) has a complex zonal structure and composition, providing it with its essential functional properties.
However, when cartilage is damaged, the zonal complexity does not regenerate, leaving an inferior tissue which is prone to degeneration.
As a result, cartilage injury commonly leads to pain and the eventual need for joint replacement.
Progress towards true regeneration of AC requires an advance in understanding of how zonal complexity (and corresponding function) emerge…
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
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