CORDIS Project
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This project investigates how mechanical forces activate Rho proteins and their role in cellular adaptation, particularly during cardiovascular diseases. It employs biochemical assays and advanced microscopy to explore these mechanisms in both laboratory and animal models.
As molecular links between mechanosensors and the regulation of cellular processes Rho proteins have a critical position in mechanotransduction.
Interestingly during cardiovascular disease (CVD) involving aberrant hemodynamic forces Rho proteins are activated.
How do mechanical forces regulate Rho proteins?
How do they contribute to the mechanical adaptation of the cell?
And How is this mechanism altered during CVD?
To answer these questions we have designed a proposal in two phases with interdi…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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