CORDIS Project
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This project investigates the role of specific kinases in the invasion of red blood cells by the malaria parasite Plasmodium falciparum. It aims to identify essential kinases localized in rhoptry organelles and understand their regulatory impact on proteins critical for the parasite's lifecycle.
Malaria remains a major global health issue, caused by the apicomplexan parasites of the genus Plasmodium, with Plasmodium falciparum being the most virulent and lethal species.
Malaria symptoms primarily result from repetitive cycles of parasite invasion, replication and egress within human red blood cells (RBCs).
Invasion by the infective merozoite forms is facilitated by the secretion of factors from apically localized secretory organelles.
Among these, the largest, known as rhoptries, contai…
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