CORDIS Project
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This research explores the mechanisms behind dilated cardiomyopathy, particularly focusing on the role of the filamin C protein in heart function. It aims to understand how its deficiency leads to heart failure and arrhythmias using experimental and mathematical models.
Heart failure is a major cause of death in the Western world, with an estimated prevalence of 2-3\% of the population.
A subgroup of heart failure patients is characterised by dilated cardiomyopathy (DCM) which results in substantial morbidity and mortality due to progressive mechanical pump failure (70\%) or sudden cardiac death from ill-predictable electrical disturbances (30\%).
DCM is commonly linked to mutations encoding cytoskeletal proteins, but our understanding of why a loss of cardiac…
ALBERT-LUDWIGS-UNIVERSITAET FREIBURG
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
LOS ANGELES UCLA SANTA BARBARA UCSB DAVIS UCD RIVERSIDE UCR SAN DIEGO UCSD SANTA CRUZ UCSC IRVIN
United States, Berkeley
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN
Germany, Bonn
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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