CORDIS Project
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This project investigates how mutations in ribosomal protein genes lead to defective ribosomes that escape cellular quality control and participate in protein synthesis. Using yeast models and advanced techniques like ribosome profiling, it aims to understand the implications of these mutations on ribosome function and…
Ribosomes are RNA-protein complexes found in all living cells.
Ribosome biogenesis is a complex, cellular process that is tightly coordinated with ribosomes demand to ensure optimal cellular adaptation, growth and proliferation.
In eukaryotes, ribosomes are sequentially generated in key steps where the ribosomal RNA (rRNA) is folded, modified, processed, and assembled with ribosomal proteins (r-proteins) to form the two ribosomal subunits.
Recently, the connection of defective ribosome biogenesi…
UNIVERSIDAD DE SEVILLA
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