CORDIS Project
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This project investigates how variations in ribosome composition influence cell identity and differentiation in multicellular organisms, particularly in blood cell development and related diseases. By examining ribosome heterogeneity, the research aims to uncover new regulatory mechanisms of gene expression that could…
Differentiation and acquisition of cell identity are fundamental processes in multi-cellular organisms.
It is well established that chromatin and RNA mechanisms regulate cell fate determination.
Mounting evidence from our lab and others, however, suggests that translation is an additional, until now underappreciated, determinant of cell fate.
The importance of translation to differentiation can be gleaned from the hematopoietic system, where a prominent feature of human congenital syndromes, due…
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