CORDIS Project
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This project investigates the role of riboswitches in regulating vitamin B1 metabolism in the green alga Chlamydomonas reinhardtii. It aims to understand gene expression control and its implications for nutritional quality and biofuel production.
Thiamine pyrophosphate (TPP) is the active form of vitamin B1.
As well as being an important cofactor for primary metabolism, TPP also controls gene regulation through riboswitches in bacteria, fungi, plants and algae.
Riboswitches are evolutionarily conserved sequences in the mRNA to which a metabolite binds directly, thereby affecting expression of the protein.
In the green alga Chlamydomonas reinhardtii, riboswitches have been found to control gene expression of two thiamine genes, THIC and T…
UNIVERSITE DE GENEVE
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