CORDIS Project
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This project investigates how cells maintain protein balance under stress by examining the structural changes in the translation machinery using cryo-electron tomography. It aims to understand the cellular responses to heat shock and protein misfolding, which are critical in neurodegenerative diseases.
Many cellular and extracellular events cause perturbations of protein homeostasis by affecting either de novo protein folding or by destabilizing already folded proteins.
Under such proteotoxic stress conditions, cells engage in various strategies to avoid further damage to the cellular proteome, e.g. by timely modulation of translation activity and specificity, or by resolving the underlying events.
Our overall goal is to dissect from a unique structural angle how such damage avoidance strategi…
RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
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