CORDIS Project
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This project investigates early-onset inflammatory bowel disease caused by mutations in the IL10 gene or its receptor. It aims to identify affected patients and understand the mechanisms behind their severe symptoms through genetic analysis and immune cell studies.
ObjectivesWe have discovered that early-onset inflammatory bowel disease (IBD) can be caused by mutations in IL10 or its receptor.
This project aims to identify further patients suffering from IL10/IL10 receptor deficiency and to clarify the pathomechanism causing the severe phenotype of the patients.DesignThe project will investigate patients with early-onset IBD.
Patients will have blood samples taken, white blood cells will be separated, DNA isolated and functional assays and genetic analyses…
UNIVERSITAETSKLINIKUM FREIBURG
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