CORDIS Project
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This study focuses on chronic granulomatous disease, a genetic condition leading to abnormal inflammation. It aims to understand how a deficiency in NADPH oxidase affects macrophage behavior and granuloma formation, with the goal of identifying new treatment strategies.
Chronic granulomatous disease (CGD) affects children and young adults and is associated with significant morbidity, mortality and socio-economic costs. CGD is caused by the genetic deficiency of NADPH oxidase (Nox).
The characteristic lesion in CGD is the development of granulomas, or confined areas of tissue inflammation, which are characterized by the presence of macrophages (Mph) and Mph-derived multinucleated giant cells.
Granulomas physiologically function to wall off microorganisms or for…
UNIVERSITAETSKLINIKUM FREIBURG
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