CORDIS Project
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This research investigates the roles of mitochondrial proteins SIRT3 and SIRT5 in liver metabolism and cancer. By creating genetically modified mice, the project aims to understand how these proteins affect responses to metabolic stresses and their potential involvement in liver tumor development.
The function of the three mitochondrial sirtuins SIRT3, 4, and 5 is poorly understood at present.
As a limited number of studies have focused on SIRT3, its exact function and regulation in mammalian physiology need still to be elucidated.
Likewise, beyond its recently discovered role in the regulation of carbamoyl phosphate synthase 1 (CPS1), nothing is known about the function of SIRT5, one of the other mitochondrial deacetylases from the sirtuin family.
The present research project proposes to…
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
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