CORDIS Project
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This project investigates how non-coding RNA influences gene expression through chromatin remodelling in cancer. By identifying specific RNA transcripts and their interactions with chromatin-modifying enzymes, the research aims to uncover new mechanisms of gene inactivation that contribute to cancer development.
Epigenetics describes the modification of gene expression without changing the DNA sequence.
It is now well established that epigenetics plays a major role in cancer development.
The Clark lab in which Dr.
Coolen currently works (Sydney, Australia), has discovered that such epigenetic changes in cancer are not always localised to individual genes, but can encompass large chromosomal regions resulting in silencing of neighbouring genes (“Long Range Epigenetic Silencing” or LRES).
They have now es…
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