CORDIS Project
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This project explores the role of coenzyme-linked RNAs in biology, focusing on how these modifications can influence RNA function and localization. It aims to develop new methods to identify and characterize these modified RNAs across different organisms.
Background:
RNA is an important regulator in biology.
Recently we discovered the ubiquitous redox coenzyme nicotinamide adenine dinucleotide (NAD) to be attached to bacterial RNAs in a cap-like manner, and to modulate the functions of these RNAs, and others identified NAD-RNAs in eukaryotes.
Enzymes were discovered that synthesize or break down NAD-RNAs.Scientific problems:
NAD is just one of many coenzymes and metabolic intermediates that carry a nucleotide moiety which is not involved in the c…
RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
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