CORDIS Project
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This project investigates the role of the exonuclease XRN1 in viral infections, particularly focusing on its involvement in the degradation of host mRNA. It aims to uncover the mechanisms of XRN1 activation and its significance in the lifecycle of viruses.
Commandeering the cellular gene expression machinery is essential for viruses in order to replicate their genome and ensure the production of their progeny.
One of the major events occurring during viral infection is the virus-induced host mRNA degradation, process orchestrated by the exonuclease XRN1.
However, the exact role of this enzyme remains controversial and largely elusive.
An exciting stepping stone for studying XRN1 involvement in virus infection is the observation that human cells de…
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