CORDIS Project
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This project investigates how RNA fate decisions are made during transcription in human cells. By studying the interactions of RNA with proteins, particularly the cap-binding complex, the research aims to understand the mechanisms that determine the stability and function of various RNA molecules.
High-throughput transcriptomic analyses in human cell lines have found that >80% of the genome is transcriptionallyactive. A major part of this massive genomic output is derived from RNA polymerase II (RNAPII) activity; such as, mRNA,sn(o)RNA and long non-coding RNA.
However, although these transcripts all contain 5’-m7G caps, which are commonhallmarks of RNAPII-derived transcripts, their fates differ substantially as some are rapidly degraded while others remainstable and exercise diverse funct…
AARHUS UNIVERSITET
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