CORDIS Project
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This project investigates the role of small non-coding RNAs in the DNA damage response, particularly after DNA double-strand breaks. By using targeted oligonucleotides, the aim is to modulate cellular responses to DNA damage in laboratory and animal models.
The DNA damage response (DDR) is a set of cellular events that follow the generation of a DNA damage.
We have previously discovered a novel class of small non-coding RNAs, named DNA damage RNAs (DDRNAs), which are necessary for the full DDR activation upon a DNA double-strand break generation.
Our preliminary data show that also at damaged/dysfunctional telomeres telomeric transcrips are produced.
By using antisense oligonucleotides (ASOs) targeting them, we aim at modulating DDR in cultured cel…
IFOM-ISTITUTO FONDAZIONE DI ONCOLOGIA MOLECOLARE ETS
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Italy, MILANO
Type: Company (for-profit)
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
SME: No
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