CORDIS Project
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This project investigates how small interfering RNAs guide the RNA-Induced Transcriptional Silencing complex to modify chromatin in the fission yeast Schizosaccharomyces pombe. It aims to clarify the molecular mechanisms of heterochromatin formation and the interactions between RNAi components and chromatin-modifying p…
RNA interference (RNAi) mediates chromatin modifications in fungi, plants, drosophila and vertebrates.
In the fission yeast Schizosaccharomyces pombe, where the molecular mechanisms are the most detailed, it is believed that small interfering RNAs (siRNAs) guide the RNA-Induced Transcriptional Silencing (RITS) complex to specific chromatin regions to trigger formation of heterochromatin.
Although it is clear that siRNAs are required for RITS localization to chromatin, important events of RITS si…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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