CORDIS Project
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This project explores RNA interference (RNAi) mechanisms in fission yeast and human cells to understand gene regulation and heterochromatin assembly. It aims to uncover how RNAi influences genome activity and could inform the development of RNAi-based therapies for human diseases.
RNA interference (RNAi) is a highly conserved, sequence-specific gene regulatory mechanism among eukaryotes.
It is critical for a variety of important biological functions and is being pursued as a promising new tool for the treatment of a variety of human maladies. A surprising link between heterochromatin and the RNAi pathway was discovered a few years ago in fission yeast and plants, and similar mechanisms have more recently been described in various eukaryotes.
However, to what extent the me…
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION
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