CORDIS Project
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This project aims to explore the connection between small CAG-repeated RNA toxicity and the DNA damage response in Huntington's disease. By examining how these small RNAs affect neuronal health, the research seeks to enhance understanding of the disease's mechanisms and potential therapeutic targets.
Huntington´s disease (HD) is an incurable and fatal neurodegenerative disease, manifested by a progressive loss of neurons, causing neuronal motor dysfunction, cognitive decline and death.
The disease is caused by a CAG repeat expansion in the Huntingtin (HTT) gene.
The CAG expansion induces a neurotoxic effect, mainly thought to be caused by the expanded protein.
However, also expanded RNA transcripts can cause toxicity by generation of small CAG-repeated RNAs.
Generation of these small RNAs de…
FUNDACIO CENTRE DE REGULACIO GENOMICA
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