CORDIS Project
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This project investigates the role of G-quadruplex structures in RNA, focusing on their functional contributions to translation and telomere biology. By identifying these structures within cellular RNA on a genome-wide scale, it aims to enhance our understanding of their biological significance.
For over a decade, our research programme has focused on the chemical biology of nucleic acids.
The structure of nucleic acids is key to their biological functions, and the four-stranded guanine rich class of structures called G-quadruplexes constitute a particularly intriguing motif.
Recent evidence suggests a role for G-quadruplex (G4) structures in RNA leaving their fundamental importance in biology open for exploration.
Our central hypothesis is that the G4 structural motif, rather than its…
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