CORDIS Project
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This project investigates the role of genetic diversity in RNA viruses, particularly focusing on the poliovirus and Coxsackie B3 virus. By altering the fidelity of viral RNA polymerases, it aims to understand how genetic variation affects viral infectivity and pathogenicity.
RNA viruses have the highest mutation frequencies in nature, which are in large part attributed to the low fidelity of their viral RNA-dependent RNA polymerases (RdRp).
Explosive replication kinetics coupled with high mutation rates quickly generate highly diverse populations (quasispecies) maintained by mutation-selection balance. RNA virus quasispecies have been observed for nearly all RNA viruses, but whether genetic heterogeneity is a function or consequence of a the virus’ interaction with…
INSTITUT PASTEUR
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