CORDIS Project
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This project aims to understand the role of ribonucleoprotein complexes in development and disease, particularly in neurodegenerative conditions. It focuses on the dynamics of RNA-binding proteins and their interactions, seeking to manipulate these processes to mitigate toxicity in disease contexts.
Ribonucleoprotein complexes (RNPs) play many key regulatory roles in development.
Moreover, mutations causing cancer or neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), often occur in RNA-binding proteins (RBPs).
These mutations are concentrated in the intrinsically disordered regions (IDRs), which play a central role in the control of RNP assembly and disassembly. RNP dynamics is often driven by multivalent interactions that are mediated by multiple elements within IDRs…
KEMIJSKI INSTITUT
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United Kingdom, London
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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