CORDIS Project
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This project investigates how peritoneal dialysis affects immune cells in patients with renal failure, focusing on the biology of monocytes and macrophages. The goal is to understand how these changes impact infection susceptibility and treatment outcomes, potentially leading to improved therapies for patients undergoi…
Recurrent infection remains the major reason for treatment failure in patients treated for renal failure with peritoneal dialysis (PD).
The underlying hypothesis of this study is that modification of peritoneal monocyte/macrophage biology by PD alters tissue homeostasis, susceptibility to infection and the development of immunity to re-infection, compromising the long-term potential of peritoneal dialysis as a therapy.In spite of their role in peritoneal host defence and tissue homeostasis, the…
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