CORDIS Project
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This project investigates the mechanisms behind acute kidney injury (AKI) and its progression to chronic kidney disease (CKD). It focuses on the role of endocycles in tubular epithelial cells and their potential contribution to kidney recovery and disease development using advanced animal models and human cell cultures…
Acute kidney injury (AKI) is a global public health concern which results in 1.7 million deaths per year.
If not lethal in the acute phase, AKI is considered reversible as suggested by recovery of renal function.
However, even mild AKI episodes carry substantial risk of developing subsequent chronic kidney disease (CKD).
The pathophysiological basis for this phenomenon remains unclear.
Injury and death of tubular cells are recognized as the main factors in the pathogenesis of AKI and functional…
UNIVERSITA DEGLI STUDI DI FIRENZE
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