CORDIS Project
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This project investigates the mechanisms that synaptic terminals use to maintain their function and health in the face of stress and misfolded proteins, particularly in the context of neurodegenerative diseases like Parkinson's. Using advanced genetic and screening techniques, the research aims to uncover how synaptic…
Neurodegeneration is characterized by misfolded proteins and dysfunctional synapses.
Synapses are often located very far away from their cell bodies and they must therefore largely independently cope with the unfolded, dysfunctional proteins that form as a result of synaptic activity and stress.
My hypothesis is that synaptic terminals have adopted specific mechanisms to maintain robustness over their long lives and that these may become disrupted in neurodegenerative diseases.
Recent evidence…
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