CORDIS Project
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This project investigates how modifications to DNA and histones regulate gene expression, particularly in the context of cancer. It aims to identify proteins that recognize these modifications, providing insights into epigenetic regulation and potential therapeutic targets.
The normal expression of genes is tightly regulated.
Modifications on histones or on DNA play a central role in the control of gene expression and errors in their regulation often result in diseases such as cancer.
These modifications can recruit proteins that regulate chromatin function.
Since chromatin is a large macromolecular assembly, modifications most likely act in a concerted manner.
However, it is still unclear how the information encoded in combinatorial modification patterns on the DN…
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
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IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom, LONDON
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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