CORDIS Project
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This project explores the role of syndecan-4 in cardiac fibroblast physiology, focusing on how mechanical stress influences fibrosis. By developing an in vitro model, it aims to uncover mechanisms behind myofibroblast differentiation and potential therapeutic targets for heart failure.
Cardiac fibrosis is a major cause of diastolic heart failure, a condition affecting millions of people worldwide.
Treatment is currently lacking, reflecting a lack of understanding of cardiac fibroblast physiology, the main cell type responsible for extracellular matrix (ECM) production and development of fibrosis.
Mechanical stress activates cardiac fibroblasts causing differentiation into myofibroblasts with excessive production of ECM. I previously showed that syndecan-4 (SDC4) is essential f…
KOBENHAVNS UNIVERSITET
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