CORDIS Project
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This project investigates the fluorescence properties of metabolic coenzymes NADH and FAD using advanced microscopy techniques. By addressing spectral crosstalk from cellular components, it aims to improve the accuracy of metabolic monitoring in live tissues, enhancing diagnostic capabilities for metabolic diseases.
Metabolic dysregulation is a hallmark of numerous diseases.
Multiphoton microscopy (MPM) combined with fluorescence lifetime imaging (FLIM) of the metabolic coenzymes NADH and FAD has emerged as a key method for monitoring metabolic processes in live tissue with sub-cellular resolution.
However, recent data demonstrates that spectral crosstalk from other cellular components, such as keratin, is substantial.
Yet the contributions from endogenous proteins are often neglected, bringing into questio…
UGOT - GOETEBORGS UNIVERSITET/UNIVERSITY OF GOTHENBURG
GOETEBORGS UNIVERSITET
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