CORDIS Project
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This project investigates the human zinc finger antiviral protein (ZAP) and its cofactors, focusing on their role in inhibiting respiratory viruses like Influenza A and SARS-CoV-2. It aims to explore the therapeutic potential of MALT-1 inhibitors to enhance ZAP's antiviral activity while assessing potential side effect…
The human zinc finger antiviral protein (ZAP) is capable of inhibiting several major human pathogens, including Influenza A virus and SARS-CoV-2. ZAP specifically targets CpG dinucleotides in RNAs and might be one of the reasons why CpGs are strongly suppressed in the human genome.
Successful viruses, such as HIV-1 and SARS-CoV-2, mimic human CpG suppression to partially evade the inhibitory effects of ZAP.
However, especially under conditions of infection or inflammation when ZAP is expressed a…
UNIVERSITAET ULM
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