CORDIS Project
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This project focuses on the interactions between the bacterium Shigella flexneri and human intestinal cells during infection. It aims to study how Shigella proteins, particularly the IpaH family, manipulate host cell functions to promote bacterial survival and infection.
Numerous pathogens grow inside host cells.
During the intracellular stage of infection, pathogen proteins establish intricate interactions with host proteins to hijack their cellular machinery.
The bacterium Shigella flexneri thrives in the cytoplasm of human intestinal epithelial cells.
To do so this bacterium must inject proteins that are dubbed effectors before and after cell invasion.
IpaH are an uncommonly large family of effectors, comprising 9 members, for example, in S. flexneri 5.
Thes…
INSTITUT PASTEUR
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