CORDIS Project
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This project investigates the role of Vascular Endothelial Growth Factor (VEGF) and angiogenesis in the development of leukemia. It aims to understand how the transcription factor HIF-1α influences VEGF expression in leukemic cells and its impact on normal blood cell formation and leukemia progression through a combina…
Our interest is to understand the role of VEGF expression and angiogenesis in leukemogenesis.
Recently, emerging data is suggesting that in addition to promoting the growth and metastatic spread of solid tumors, angiogenesis may play an important role also in the pathophysiology of hematological malignancies.
Clinical studies indicate that leukemia patients express high levels of pro-angiogenic factors such as VEGF and have increased angiogenesis in the bone marrow.
However, these findings are m…
OSPEDALE SAN RAFFAELE SRL
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