CORDIS Project
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This project investigates the regulation of the PU.1 gene, crucial for blood cell development, by studying the role of antisense RNAs. It aims to understand how these RNAs influence chromatin structure and gene expression during hematopoietic stem cell differentiation, with implications for leukemia and lymphoma.
PU.1 levels are critical for normal hematopoiesis and, even modest alterations can lead to leukemia and lymphoma.
To achieve optimal expression of the PU.1 gene at different stages of hematopoiesis, multiple interactions are required between its regulatory elements to form fine chromatin architecture.
While significant advances have been made in understanding which PU.1 locus chromatin states are active or silent, nothing is known how these states are propagated and maintained.
The overall goal…
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Austria, Graz
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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