CORDIS Project
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This research investigates the role of the small GTPase Arl13b in regulating membrane trafficking in cells. It aims to understand how Arl13b influences the recycling of lipid antigen presenting molecules and other cargo within cellular compartments.
To move cargo between specific membrane-bound intracellular compartments, eukaryotic cells have evolved numerous mechanisms of membrane trafficking regulation.
We found that CD1a, an MHC Class I-like lipid antigen presenting molecule follows an endocytic recycling pathway similar to that used by MHC Class I and other cargo internalized independently of clathrin.
In an attempt to discover new regulators of this pathway, we screened a shRNA library for changes in CD1a surface expression and we fou…
FACULDADE DE CIENCIAS MEDICAS DA UNIVERSIDADE NOVA DE LISBOA
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